Complete clinical response to combined antifungal therapy in two cats with invasive fungal rhinosinusitis caused by cryptic Aspergillus species in section Fumigati

Complete clinical response to combined antifungal therapy in two cats with invasive fungal rhinosinusitis caused by cryptic Aspergillus species in section Fumigati

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Cryptic species in Aspergillus section Fumigati are increasingly reported to cause invasive aspergillosis in UNDERWEAR humans and animals.These infections are often refractory to treatment because of intrinsic antifungal resistance.We report two cases of invasive fungal rhinosinusitis in domestic cats caused by A.udagawae and A.felis.

Clinical signs resolved after combined therapy including Neck Ties posaconazole, caspofungin and terbinafine.Both cases remained asymptomatic more than 2 years from initial presentation.